Red cheeks to red cell aplasia: parvovirus B19 in a heart transplant patient
نویسندگان
چکیده
منابع مشابه
Parvovirus B19–induced pure red cell aplasia in a heart transplant recipient.
A 29-year-old female presented with unexplained anemia (hemoglobin 77 g/L) 5 years after orthoptic heart transplantation. She was being treated with high-dose immunosuppression. The blood film demonstrated a normochromic normocytic anemia. The white cell and platelet counts were normal. There was reticulocytopenia (1 109/L, 0.04%) and an elevated erythropoietin (356 U/mL; normal, 5-18.5 U/mL) w...
متن کاملPure red cell aplasia caused by parvovirus B19 in a heart transplant recipient
A case of parvovirus B19-induced pure red cell aplasia occurring in a heart transplant recipient is reported. The diagnosis of this rare but clinically important complication can be suspected on the basis of the pathognomonic morphological features of the bone marrow.
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A 56-year-old woman was diagnosed with mycosis fungoides 10 years earlier. Her cutaneous manifestations were widespread patches, plaques, and ultimately tumor nodules. Her disease was refractory to standard therapies, and she had no histocompatible sibling. She subsequently entered a phase 2 clinical trial of alemtu-zumab (Campath-1H) for cutaneous T-cell lymphoma (CTCL). After 2 weeks' treatme...
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Rituximab is a chimeric monoclonal antibody directed against CD20 and used in the treatment of B-cell non-Hodgkin's lymphoma. Due to its ability to deplete B lymphocytes, rituximab can interfere with humoral immunity, causing it to be suppressed for several months after treatment. The reported case depicts a serious consequence of this effect of rituximab therapy: pure red cell aplasia resultin...
متن کاملPure Red Cell Aplasia due to B19 Parvovirus Infection after Autologous Stem Cell Transplantation
Parvovirus B19 is recognized as a rare cause of pure red cell aplasia (PRCA) in allogeneic stem cell (SCT) and solid organ transplant patients. We report a patient with Hodgkin's disease who developed PRCA due to parvovirus B19 after autologous SCT and who had an excellent response after treatment with gamma-globulin.
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ژورنال
عنوان ژورنال: Blood
سال: 2017
ISSN: 0006-4971,1528-0020
DOI: 10.1182/blood-2017-05-785691